DOXAPRAM - INJECTION (Dopram) side effects, medical uses.

Consumer information about the medication DOXAPRAM - INJECTION (Dopram), includes side effects, drug interactions, recommended dosages, and storage information. Read more about the prescription drug DOXAPRAM - INJECTION.

Doxapram was extensively metabolised, and less than 5% of an I.V. dose was excreted unchanged in the urine in 24 hours. 5.3 Preclinical safety data. Reproduction studies have been performed in rats at doses up to 1.6 times the human dose and have revealed no evidence of impaired fertility or harm to the foetus associated with the use of doxapram. Acute toxicity studies in several animal.

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Doxapram should be administered with caution to patients with significantly impaired hepatic or renal function as a reduction in the rate of metabolism or excretion of metabolites may alter the response. In Postanesthetic Use a. The same consideration to pre-existing disease states should be exercised as in non- anesthetized individuals. See CONTRAINDICATIONS and WARNINGS covering use in.

Doxapram has a short duration of action requiring frequent or CRI administration, which limits use despite evidence of improved ventilation compared with caffeine. 87 Disadvantages of doxapram use include an increase in myocardial oxygen consumption and cost. Theophylline is similar to caffeine; however, it has a narrow therapeutic index with adverse effects including colic, seizure.

Find patient medical information for Doxapram Intravenous on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

Following doxapram administration, an increased release of catecholamines has been noted. 5.2 MeSH Pharmacological Classification. Central Nervous System Stimulants. A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as.

The effects of doxapram on cerebral blood flow (CBF) and peripheral hemodynamics were evaluated in the goat after direct injection into the cerebral circulation and after peripheral IV administration. Doxapram injected centrally via the temporal artery, in doses too small to affect peripheral circulation, produced an immediate and prolonged decrease in CBF in both anesthetized and.

Doxapram has the following interaction information: Aminophylline. Aminophylline increases the risk of agitation when given with doxapram. Manufacturer advises caution. Severity of interaction: Moderate Evidence for interaction: Study. Isocarboxazid. Isocarboxazid is predicted to increase the effects of doxapram. Manufacturer advises caution. Severity of interaction: Moderate Evidence for.

Dopram Pharmacologic class: CNS and respiratory stimulant Therapeutic class: Analeptic Pregnancy risk category B Action Activates peripheral carotid, aortic, and other chemoreceptors to stimulate respiration. Increases tidal volume and respiratory rate by directly stimulating respiratory center in medulla oblongata. Availability Injection: 20.

Doxapram. Doxapram is a pyrrolidinone derivative with CNS-stimulant (analeptic) effects. Its mechanism of action, though still unclear, is believed to involve stimulation of both central and peripheral chemoreceptors, which then leads to stimulation of ventral brainstem nuclei and subsequent increased depth and rate of respiration. 234 In a study of 83 full-term infants, doxapram given at.